Assay Detail
Binding
CHEMBL2447453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Cy5-pNPY from human Y5 receptor expressed in human HEC-1B cells after 90 to 120 mins by flow cytometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane and cis-cyclopentane β-amino acids shifts selectivity toward the Y(4) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.22 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438945 | HUMAN NEUROPEPTIDE Y | 1.0 | 1 | 8.66 |
| CHEMBL2440192 | — | — | 1 | 7.77 |
| CHEMBL2440199 | — | — | 1 | - |
| CHEMBL2440185 | — | — | 1 | - |
| CHEMBL2440186 | — | — | 1 | - |
| CHEMBL2440187 | — | — | 1 | - |
| CHEMBL2440188 | — | — | 1 | - |
| CHEMBL2440189 | — | — | 1 | - |
| CHEMBL2440190 | — | — | 1 | - |
| CHEMBL2440191 | — | — | 1 | - |
| CHEMBL2440200 | — | — | 1 | - |
| CHEMBL2440193 | — | — | 1 | - |
| CHEMBL2440194 | — | — | 1 | - |
| CHEMBL2440195 | — | — | 1 | - |
| CHEMBL2440196 | — | — | 1 | - |
| CHEMBL2440197 | — | — | 1 | - |
| CHEMBL2440198 | — | — | 1 | - |
| CHEMBL2440119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438945 | HUMAN NEUROPEPTIDE Y | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2440192 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2440199 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440185 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440186 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440187 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2440188 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440189 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440190 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2440191 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440200 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440193 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440194 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440195 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2440196 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440197 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440198 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2440119 | — | Ki | > | 1000.0 | nM | - |