Assay Detail
Functional
CHEMBL2447643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.76 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441391 | — | — | 1 | 6.75 |
| CHEMBL2441375 | — | — | 1 | 6.72 |
| CHEMBL2441377 | — | — | 1 | 5.70 |
| CHEMBL2441383 | — | — | 1 | 5.68 |
| CHEMBL2441379 | — | — | 1 | 5.51 |
| CHEMBL2441392 | — | — | 1 | 5.50 |
| CHEMBL2441376 | — | — | 1 | 5.28 |
| CHEMBL2441393 | — | — | 1 | 4.96 |
| CHEMBL2441378 | — | — | 1 | - |
| CHEMBL2441374 | — | — | 1 | - |
| CHEMBL2441395 | — | — | 1 | - |
| CHEMBL2441394 | — | — | 1 | - |
| CHEMBL2441382 | — | — | 1 | - |
| CHEMBL2441380 | — | — | 1 | - |
| CHEMBL2441390 | — | — | 1 | - |
| CHEMBL2441388 | — | — | 1 | - |
| CHEMBL2441387 | — | — | 1 | - |
| CHEMBL2440131 | — | — | 1 | - |
| CHEMBL2441386 | — | — | 1 | - |
| CHEMBL2441385 | — | — | 1 | - |
| CHEMBL2441384 | — | — | 1 | - |
| CHEMBL1761258 | — | — | 1 | - |
| CHEMBL2441381 | — | — | 1 | - |
| CHEMBL2441389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441391 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2441375 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2441377 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2441383 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2441379 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2441392 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2441376 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2441393 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2441378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441374 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441380 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441390 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441388 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441387 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2440131 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441386 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441385 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761258 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441381 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441389 | — | IC50 | > | 10000.0 | nM | - |