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Assay Detail

CHEMBL2448754

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
DNDI: Chagas in Vitro
ChEMBL ↗
129
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi. Exported from HEOS 25-Oct-2013. See also related datasets CHEMBL3137440 and CHEMBL3137386.
Martine Keenan, Paul W. Alexander, Jason H Chaplin, Michael J Abbott, Hugo Diao, Zhisen Wang, Wayne M Best, Catherine J Perez, Scott MJ Cornwall, Sarah K Keatley, RC Andrew Thompson, Susan A Charman, Karen L White, Eileen Ryan, Gong Chen, Jean-Robert Ioset, Thomas W von Geldern, Eric Chatelain

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 129 7.70 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2448735 — — 5 10.00
CHEMBL2448747 — — 4 9.72
CHEMBL2448750 — — 8 9.59
CHEMBL2448749 — — 4 9.48
CHEMBL2448716 — — 2 9.21
CHEMBL2448698 — — 2 9.10
CHEMBL2448741 — — 2 9.00
CHEMBL2448739 — — 1 8.70
CHEMBL2448745 — — 2 8.66
CHEMBL2448738 — — 1 8.60
CHEMBL2448748 — — 4 8.60
CHEMBL2448717 — — 1 8.57
CHEMBL2448736 — — 2 8.53
CHEMBL2448694 — — 1 8.52
CHEMBL2448704 — — 2 8.52
CHEMBL2448724 — — 3 8.49
CHEMBL2448752 — — 2 8.28
CHEMBL2448721 — — 2 8.22
CHEMBL2448712 — — 4 8.22
CHEMBL2448719 — — 2 8.18
CHEMBL2448689 — — 2 8.05
CHEMBL2448726 — — 6 7.96
CHEMBL2448720 — — 1 7.89
CHEMBL2448713 — — 1 7.89
CHEMBL2448742 — — 1 7.87
CHEMBL2448723 — — 1 7.87
CHEMBL2448740 — — 1 7.81
CHEMBL2448697 — — 1 7.80
CHEMBL2448744 — — 1 7.77
CHEMBL2448733 — — 1 7.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2448735 — IC50 = 0.1 nM 10.00
CHEMBL2448735 — IC50 = 0.15 nM 9.82
CHEMBL2448747 — IC50 = 0.19 nM 9.72
CHEMBL2448735 — IC50 = 0.19 nM 9.72
CHEMBL2448747 — IC50 = 0.2 nM 9.70
CHEMBL2448747 — IC50 = 0.22 nM 9.66
CHEMBL2448750 — IC50 = 0.26 nM 9.59
CHEMBL2448750 — IC50 = 0.31 nM 9.51
CHEMBL2448749 — IC50 = 0.33 nM 9.48
CHEMBL2448749 — IC50 = 0.43 nM 9.37
CHEMBL2448735 — IC50 = 0.58 nM 9.24
CHEMBL2448716 — IC50 = 0.6167 nM 9.21
CHEMBL2448735 — IC50 = 0.69 nM 9.16
CHEMBL2448698 — IC50 = 0.8 nM 9.10
CHEMBL2448749 — IC50 = 0.85 nM 9.07
CHEMBL2448716 — IC50 = 0.9 nM 9.05
CHEMBL2448741 — IC50 = 1.0 nM 9.00
CHEMBL2448739 — IC50 = 1.975 nM 8.70
CHEMBL2448741 — IC50 = 2.0 nM 8.70
CHEMBL2448745 — IC50 = 2.2 nM 8.66
CHEMBL2448748 — IC50 = 2.5 nM 8.60
CHEMBL2448738 — IC50 = 2.533 nM 8.60
CHEMBL2448745 — IC50 = 2.6 nM 8.59
CHEMBL2448717 — IC50 = 2.7 nM 8.57
CHEMBL2448736 — IC50 = 2.933 nM 8.53
CHEMBL2448704 — IC50 = 3.0 nM 8.52
CHEMBL2448694 — IC50 = 3.0 nM 8.52
CHEMBL2448724 — IC50 = 3.2 nM 8.49
CHEMBL2448724 — IC50 = 3.8 nM 8.42
CHEMBL2448749 — IC50 = 4.3 nM 8.37
CHEMBL2448724 — IC50 = 4.9 nM 8.31
CHEMBL2448752 — IC50 = 5.3 nM 8.28
CHEMBL2448748 — IC50 = 5.2 nM 8.28
CHEMBL2448736 — IC50 = 5.5 nM 8.26
CHEMBL2448750 — IC50 = 5.6 nM 8.25
CHEMBL2448712 — IC50 = 6.0 nM 8.22
CHEMBL2448721 — IC50 = 6.0 nM 8.22
CHEMBL2448752 — IC50 = 6.2 nM 8.21
CHEMBL2448698 — IC50 = 6.5 nM 8.19
CHEMBL2448719 — IC50 = 6.625 nM 8.18
CHEMBL2448721 — IC50 = 6.7 nM 8.17
CHEMBL2448712 — IC50 = 6.8 nM 8.17
CHEMBL2448712 — IC50 = 7.0 nM 8.15
CHEMBL2448748 — IC50 = 7.2 nM 8.14
CHEMBL2448704 — IC50 = 8.0 nM 8.10
CHEMBL2448748 — IC50 = 8.8 nM 8.06
CHEMBL2448689 — IC50 = 9.0 nM 8.05
CHEMBL2448726 — IC50 = 11.0 nM 7.96
CHEMBL2448712 — IC50 = 11.5 nM 7.94
CHEMBL2448720 — IC50 = 12.9 nM 7.89