Assay Detail
Functional
CHEMBL3047620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Tobacco mosaic virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.34 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450464 | BRUSATOL | — | 1 | 5.47 |
| CHEMBL140809 | BRUCEINE B | — | 1 | 5.46 |
| CHEMBL506706 | YADANZIOSIDE I | — | 1 | 5.38 |
| CHEMBL2367701 | Bruceoside-B | — | 1 | 5.33 |
| CHEMBL2367702 | Yadanzioside L | — | 1 | 5.31 |
| CHEMBL477693 | BRUCEINE D | — | 1 | 5.28 |
| CHEMBL478566 | YADANZIOLIDE A | — | 1 | 5.26 |
| CHEMBL2228445 | YADANZIOSIDE D | — | 1 | 5.25 |
| CHEMBL458302 | NINGNANMYCIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450464 | BRUSATOL | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL140809 | BRUCEINE B | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL506706 | YADANZIOSIDE I | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL2367701 | Bruceoside-B | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL2367702 | Yadanzioside L | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL477693 | BRUCEINE D | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL478566 | YADANZIOLIDE A | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2228445 | YADANZIOSIDE D | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL458302 | NINGNANMYCIN | IC50 | = | 117300.0 | nM | - |