Assay Detail
Binding
CHEMBL3052330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) whole body membrane after 90 min by filter binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Myzus persicae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.44 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 8.51 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 8.47 |
| CHEMBL259727 | CLOTHIANIDINE | — | 1 | 8.04 |
| CHEMBL265941 | ACETAMIPRID | — | 1 | 8.00 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | — | 1 | 8.00 |
| CHEMBL2269823 | — | — | 1 | 7.89 |
| CHEMBL148390 | — | — | 1 | 7.82 |
| CHEMBL259728 | NITENPYRAM | — | 1 | 7.68 |
| CHEMBL2251730 | IMIDACLOTHIZ | — | 1 | 7.68 |
| CHEMBL2269821 | — | — | 1 | 7.25 |
| CHEMBL2269820 | — | — | 1 | 7.19 |
| CHEMBL2269818 | — | — | 1 | 6.82 |
| CHEMBL3138618 | — | — | 1 | 5.46 |
| CHEMBL2228155 | DINOTEFURAN | — | 1 | 5.30 |
| CHEMBL2269817 | — | — | 1 | - |
| CHEMBL2269819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL259727 | CLOTHIANIDINE | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL265941 | ACETAMIPRID | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2269823 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL148390 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL259728 | NITENPYRAM | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2251730 | IMIDACLOTHIZ | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2269821 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2269820 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2269818 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3138618 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2228155 | DINOTEFURAN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2269817 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2269819 | — | IC50 | > | 1000.0 | nM | - |