Compound Detail
CHEMBL2269822
DESMETHYLTHIAMETHOXAM Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2269822 |
| Name | DESMETHYLTHIAMETHOXAM |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LOXCNVOJGRNBFX-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
277.7
MW (Da)
0.68
ALogP
5
HBA
1
HBD
92.9
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
| Acetylcholine receptor subunit beta-like 2 CHEMBL2366470 | IC50 | 7.96 | 7.83 | 11.0 | 2 |
| Nicotinic acetylcholine receptor alpha 5 subunit CHEMBL2366408 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 10.0 | nM | 8.0 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae ... | 10936213 |
| Acetylcholine receptor subunit beta-like 2 | IC50 | = | 11.0 | nM | 7.96 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Aphis craccivor... | 10936213 |
| Nicotinic acetylcholine receptor alpha 5 subunit | IC50 | = | 16.0 | nM | 7.8 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Musca domestica... | 10936213 |
| Acetylcholine receptor subunit beta-like 2 | IC50 | = | 20.0 | nM | 7.7 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila mela... | 10936213 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Acetylcholine receptor subunit beta-like 2 | 3 |
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Unchecked | 2 |
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Nicotinic acetylcholine receptor alpha 5 subunit | 1 |
Data from ChEMBL 36 via Core Engine