Assay Detail
Binding
CHEMBL3052327
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Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster head membrane after 90 min by filter binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Drosophila melanogaster |
| Tissue | Head |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit beta-like 2 (CHEMBL2366470) ↗| Type | SINGLE PROTEIN |
| Organism | Drosophila melanogaster |
Publication
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.43 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259727 | CLOTHIANIDINE | — | 1 | 8.66 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 8.64 |
| CHEMBL148390 | — | — | 1 | 8.13 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 8.12 |
| CHEMBL265941 | ACETAMIPRID | — | 1 | 8.08 |
| CHEMBL259728 | NITENPYRAM | — | 1 | 7.96 |
| CHEMBL2251730 | IMIDACLOTHIZ | — | 1 | 7.77 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | — | 1 | 7.70 |
| CHEMBL2269823 | — | — | 1 | 7.66 |
| CHEMBL2269821 | — | — | 1 | 7.03 |
| CHEMBL2269820 | — | — | 1 | 6.81 |
| CHEMBL2269818 | — | — | 1 | 6.80 |
| CHEMBL3138618 | — | — | 1 | 5.33 |
| CHEMBL2228155 | DINOTEFURAN | — | 1 | 5.30 |
| CHEMBL2269817 | — | — | 1 | - |
| CHEMBL2269819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259727 | CLOTHIANIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL148390 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL265941 | ACETAMIPRID | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL259728 | NITENPYRAM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2251730 | IMIDACLOTHIZ | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2269823 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2269821 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2269820 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL2269818 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3138618 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2228155 | DINOTEFURAN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2269817 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2269819 | — | IC50 | > | 1000.0 | nM | - |