Compound Detail
CHEMBL2251730
IMIDACLOTHIZ Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2251730 |
| Name | IMIDACLOTHIZ |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OWRSHPAYDYCHSJ-UHFFFAOYSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
261.7
MW (Da)
0.75
ALogP
4
HBA
1
HBD
83.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.09
EC50 1 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholine receptor subunit beta-like 2 CHEMBL2366470 | IC50 | 8.09 | 7.93 | 8.2 | 2 |
| Nicotinic acetylcholine receptor alpha 5 subunit CHEMBL2366408 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| Nicotinic acetylcholine receptor alpha8 subunit CHEMBL2366437 | EC50 | 5.8 | 5.8 | 1584.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholine receptor subunit beta-like 2 | IC50 | = | 8.2 | nM | 8.09 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Aphis craccivor... | 10936213 |
| Nicotinic acetylcholine receptor alpha 5 subunit | IC50 | = | 12.0 | nM | 7.92 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Musca domestica... | 10936213 |
| Acetylcholine receptor subunit beta-like 2 | IC50 | = | 17.0 | nM | 7.77 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila mela... | 10936213 |
| Unchecked | IC50 | = | 21.0 | nM | 7.68 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae ... | 10936213 |
| Nicotinic acetylcholine receptor alpha8 subunit | EC50 | = | 1584.89 | nM | 5.8 | Agonist activity at Periplaneta americana (American cockroach) nAChR in terminal... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/j.cropro.2011.12.007 | Trichogramma nubilale | 3 |
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Acetylcholine receptor subunit beta-like 2 | 2 |
| - | 10.1584/jpestics.31.35 | Nicotinic acetylcholine receptor alpha8 subunit | 2 |
| 17263479 | 10.1021/jf0623440 | No relevant target | 1 |
| 17263479 | 10.1021/jf0623440 | Periplaneta americana | 1 |
| 17263479 | 10.1021/jf0623440 | Nicotinic acetylcholine receptor alpha8 subunit | 1 |
| 20879794 | 10.1021/jf102525e | No relevant target | 1 |
| 20879794 | 10.1021/jf102525e | Periplaneta americana | 1 |
| 20879794 | 10.1021/jf102525e | Nicotinic acetylcholine receptor alpha8 subunit | 1 |
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Nicotinic acetylcholine receptor alpha 5 subunit | 1 |
| 10936213 | 10.1046/j.1471-4159.2000.751294.x | Unchecked | 1 |
| 27316887 | 10.1271/bbb.57.127 | Nephotettix cincticeps | 1 |
| - | 10.1584/jpestics.31.35 | Periplaneta americana | 1 |
| - | 10.1584/jpestics.31.35 | No relevant target | 1 |
| - | 10.1584/jpestics.R07-05 | No relevant target | 1 |
| - | 10.1584/jpestics.R07-05 | Periplaneta americana | 1 |
Data from ChEMBL 36 via Core Engine