Assay Detail
Binding
CHEMBL3052329
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Displacement of [3H]IMI from nicotinic acetylcholine receptor in Aphis craccivora (cowpea aphid) whole body membrane after 90 min by filter binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aphis craccivora |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit beta-like 2 (CHEMBL2366470) ↗| Type | SINGLE PROTEIN |
| Organism | Drosophila melanogaster |
Publication
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.25 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259727 | CLOTHIANIDINE | — | 1 | 8.64 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 8.64 |
| CHEMBL148390 | — | — | 1 | 8.36 |
| CHEMBL2251730 | IMIDACLOTHIZ | — | 1 | 8.09 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | — | 1 | 7.96 |
| CHEMBL2269823 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259727 | CLOTHIANIDINE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL148390 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2251730 | IMIDACLOTHIZ | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2269822 | DESMETHYLTHIAMETHOXAM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2269823 | — | IC50 | = | 15.0 | nM | 7.82 |