Assay Detail
Binding
CHEMBL3053704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.78 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539879 | — | — | 1 | 8.29 |
| CHEMBL2261152 | — | — | 1 | 7.55 |
| CHEMBL2261144 | — | — | 1 | 7.54 |
| CHEMBL2261145 | — | — | 1 | 7.24 |
| CHEMBL2261148 | — | — | 1 | 6.56 |
| CHEMBL2261154 | — | — | 1 | 6.25 |
| CHEMBL2261149 | — | — | 1 | 6.08 |
| CHEMBL2261153 | — | — | 1 | 5.80 |
| CHEMBL2261155 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539879 | — | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL2261152 | — | Kd | = | 28.18 | nM | 7.55 |
| CHEMBL2261144 | — | Kd | = | 28.84 | nM | 7.54 |
| CHEMBL2261145 | — | Kd | = | 57.54 | nM | 7.24 |
| CHEMBL2261148 | — | Kd | = | 275.42 | nM | 6.56 |
| CHEMBL2261154 | — | Kd | = | 562.34 | nM | 6.25 |
| CHEMBL2261149 | — | Kd | = | 831.76 | nM | 6.08 |
| CHEMBL2261153 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL2261155 | — | Kd | = | 1905.46 | nM | 5.72 |