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Compound Detail

CHEMBL2261148

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C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1.[O-][Cl+3]([O-])([O-])[O-]

Basic Information

ChEMBL ID CHEMBL2261148
Phase Preclinical
Structure Type MOL
InChI Key QKVBVXCOSXKABM-POCMBTLOSA-M
Parent Compound CHEMBL3139732
Active Moiety CHEMBL3139732
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

315.5
MW (Da)
3.44
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23ClO6S
MW 414.91
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.56

Activity Summary

Kd 6 meas. best 6.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 6.69 6.69 204.2 2
Muscarinic receptor 2
CHEMBL1075061
Kd 6.56 6.56 275.4 2
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 6.36 6.36 436.5 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-006-0143-5 Unchecked 4
- 10.1007/s00044-005-0139-6 Unchecked 4
- 10.1007/s00044-006-0143-5 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-006-0143-5 Muscarinic receptor 2 1
- 10.1007/s00044-005-0139-6 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-005-0139-6 Muscarinic receptor 2 1

Data from ChEMBL 36 via Core Engine