Assay Detail
Binding
CHEMBL3053703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Cavia porcellus (guinea pig) ileum M3 receptor after 30 min
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.21 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2261152 | — | — | 1 | 8.27 |
| CHEMBL2261150 | — | — | 1 | 7.86 |
| CHEMBL2261154 | — | — | 1 | 7.81 |
| CHEMBL2261144 | — | — | 1 | 7.69 |
| CHEMBL539879 | — | — | 1 | 7.63 |
| CHEMBL2261145 | — | — | 1 | 7.46 |
| CHEMBL2261151 | — | — | 1 | 7.13 |
| CHEMBL2261149 | — | — | 1 | 6.70 |
| CHEMBL2261153 | — | — | 1 | 6.43 |
| CHEMBL2261148 | — | — | 1 | 6.36 |
| CHEMBL2261155 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2261152 | — | Kd | = | 5.37 | nM | 8.27 |
| CHEMBL2261150 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL2261154 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL2261144 | — | Kd | = | 20.42 | nM | 7.69 |
| CHEMBL539879 | — | Kd | = | 23.44 | nM | 7.63 |
| CHEMBL2261145 | — | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL2261151 | — | Kd | = | 74.13 | nM | 7.13 |
| CHEMBL2261149 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL2261153 | — | Kd | = | 371.54 | nM | 6.43 |
| CHEMBL2261148 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL2261155 | — | Kd | = | 977.24 | nM | 6.01 |