Compound Detail
CHEMBL2261150
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Basic Information
| ChEMBL ID | CHEMBL2261150 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QPRDZNMOWOEQRF-LSOSREPGSA-M |
| Parent Compound | CHEMBL3139792 |
| Active Moiety | CHEMBL3139792 |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
312.4
MW (Da)
3.27
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 7.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 7.91 | 7.91 | 12.3 | 2 |
| Muscarinic acetylcholine receptor M3 CHEMBL5498 | Kd | 7.86 | 7.86 | 13.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Kd | = | 12.3 | nM | 7.91 | Antagonist activity at Oryctolagus cuniculus (rabbit) vas deferens M1 receptor a... | - |
| Unchecked | Kd | = | 12.3 | nM | 7.91 | Antagonist activity at Oryctolagus cuniculus (rabbit) vas deferens M1 receptor a... | - |
| Muscarinic acetylcholine receptor M3 | Kd | = | 13.8 | nM | 7.86 | Antagonist activity at Cavia porcellus (guinea pig) ileum M3 receptor after 30 m... | - |
| Muscarinic acetylcholine receptor M3 | Kd | = | 13.8 | nM | 7.86 | Antagonist activity at Cavia porcellus (guinea pig) ileum M3 receptor after 30 m... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-005-0139-6 | Unchecked | 5 |
| - | 10.1007/s00044-006-0143-5 | Unchecked | 4 |
| - | 10.1007/s00044-006-0143-5 | Muscarinic acetylcholine receptor M3 | 1 |
| - | 10.1007/s00044-006-0143-5 | Muscarinic receptor 2 | 1 |
| - | 10.1007/s00044-005-0139-6 | Muscarinic acetylcholine receptor M3 | 1 |
| - | 10.1007/s00044-005-0139-6 | Muscarinic receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine