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Compound Detail

CHEMBL539879

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C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1.[I-]

Basic Information

ChEMBL ID CHEMBL539879
Phase Preclinical
Structure Type MOL
InChI Key WTMWKFHJJKIULW-UHFFFAOYSA-M
Parent Compound CHEMBL1190002
Active Moiety CHEMBL1190002
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

298.4
MW (Da)
3.01
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H24INO2
MW 425.31
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.49

Activity Summary

Kd 6 meas. best 8.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 8.36 8.36 4.4 2
Muscarinic receptor 2
CHEMBL1075061
Kd 8.29 8.29 5.1 2
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 7.63 7.63 23.4 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-006-0143-5 Unchecked 4
- 10.1007/s00044-005-0139-6 Unchecked 4
11206470 10.1016/s0960-894x(00)00647-8 Muscarinic acetylcholine receptor M1 1
11206470 10.1016/s0960-894x(00)00647-8 Muscarinic acetylcholine receptor M2 1
11206470 10.1016/s0960-894x(00)00647-8 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-006-0143-5 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-006-0143-5 Muscarinic receptor 2 1
- 10.1007/s00044-005-0139-6 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-005-0139-6 Muscarinic receptor 2 1

Data from ChEMBL 36 via Core Engine