Assay Detail
Binding
CHEMBL3055251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of heme polymerization in Plasmodium falciparum after 15 min by liquid scintillation counting analysis in presence of [14C]-hemin chloride
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Pharmacophore-based predictive model generation for potent antimalarials targeting haem detoxification pathway
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.40 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 4.82 |
| CHEMBL375673 | — | — | 1 | 4.72 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 4.64 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.62 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.62 |
| CHEMBL533841 | CINCHONIDINE | -1.0 | 1 | 4.57 |
| CHEMBL1213257 | AMOPYROQUINE | 2.0 | 1 | 4.52 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | — | 1 | 4.50 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | — | 1 | 4.40 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 4.39 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 4.37 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | — | 1 | 4.36 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 4.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 4.33 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | — | 1 | 4.29 |
| CHEMBL343770 | TEBAQUINE | — | 1 | 4.28 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | — | 1 | 4.24 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 4.19 |
| CHEMBL170 | QUININE | 4.0 | 1 | 4.19 |
| CHEMBL468610 | — | — | 1 | 4.14 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | — | 1 | 4.14 |
| CHEMBL217786 | — | — | 1 | 4.04 |
| CHEMBL1107 | HALOFANTRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL375673 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1213257 | AMOPYROQUINE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL343770 | TEBAQUINE | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL170 | QUININE | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL468610 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL217786 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL1107 | HALOFANTRINE | IC50 | = | 180000.0 | nM | - |