Assay Detail
Binding
CHEMBL3055839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
110
Total Activities
55
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Structural insights for 3H-1, -2, -4 triazolinones as angiotensin II receptor antagonists using QSAR techniques
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| logIC50 | 55 | - | - |
| IC50 | 55 | 7.95 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419483 | — | — | 2 | 9.13 |
| CHEMBL87074 | — | — | 2 | 9.07 |
| CHEMBL312913 | — | — | 2 | 9.03 |
| CHEMBL19018 | — | — | 2 | 8.92 |
| CHEMBL431411 | — | — | 2 | 8.85 |
| CHEMBL87964 | — | — | 2 | 8.74 |
| CHEMBL87513 | — | — | 2 | 8.70 |
| CHEMBL18287 | — | — | 2 | 8.62 |
| CHEMBL87239 | — | — | 2 | 8.54 |
| CHEMBL87778 | — | — | 2 | 8.54 |
| CHEMBL313025 | — | — | 2 | 8.49 |
| CHEMBL87057 | — | — | 2 | 8.49 |
| CHEMBL315776 | — | — | 2 | 8.44 |
| CHEMBL83180 | — | — | 2 | 8.39 |
| CHEMBL422593 | — | — | 2 | 8.34 |
| CHEMBL85545 | — | — | 2 | 8.31 |
| CHEMBL84627 | — | — | 2 | 8.30 |
| CHEMBL314042 | — | — | 2 | 8.25 |
| CHEMBL278741 | — | — | 2 | 8.24 |
| CHEMBL316052 | — | — | 2 | 8.24 |
| CHEMBL85765 | — | — | 2 | 8.22 |
| CHEMBL83248 | — | — | 2 | 8.18 |
| CHEMBL87985 | — | — | 2 | 8.11 |
| CHEMBL313579 | — | — | 2 | 8.11 |
| CHEMBL82797 | — | — | 2 | 8.09 |
| CHEMBL87392 | — | — | 2 | 8.02 |
| CHEMBL86084 | — | — | 2 | 8.00 |
| CHEMBL407827 | — | — | 2 | 7.96 |
| CHEMBL314447 | — | — | 2 | 7.96 |
| CHEMBL312921 | — | — | 2 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419483 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL87074 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL312913 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL19018 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL431411 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL87964 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL87513 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL18287 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL87778 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL87239 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL313025 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL87057 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL315776 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL83180 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL422593 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL85545 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL84627 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL314042 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL278741 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL316052 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL85765 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL83248 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL313579 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL87985 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL82797 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL87392 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL86084 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL407827 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL314447 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL312921 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL87129 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL87798 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL315128 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL86255 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL86906 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL85541 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL314179 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL315615 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL85596 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL85876 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL87885 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL86613 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL87073 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL420970 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL69508 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL86143 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL86440 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL313017 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL84630 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL86741 | — | IC50 | = | 79.0 | nM | 7.10 |