Assay Detail
Binding
CHEMBL3059591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bos taurus (bovine) mitochodrial complex 1 isolated from heart submitochondrial particle by NADH oxidase assay
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NADH-ubiquinone oxidoreductase chain 1 (CHEMBL4497) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Total synthesis of cis-solamin and its inhibitory action with bovine heart mitochondrial complex I
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.50 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159657 | BULLATACIN | — | 1 | 9.10 |
| CHEMBL445024 | COROSSOLINE | — | 1 | 8.82 |
| CHEMBL2269127 | (10S)-COROSSOLINE | — | 1 | 8.70 |
| CHEMBL396297 | CIS-SOLAMIN | — | 2 | 8.68 |
| CHEMBL2269126 | (17R,18R,21R,22S)-reticulation-1 | — | 1 | 7.80 |
| CHEMBL2269125 | (17S, 18S, 21S, 22R)-reticulation-1 | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159657 | BULLATACIN | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL445024 | COROSSOLINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2269127 | (10S)-COROSSOLINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL396297 | CIS-SOLAMIN | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL396297 | CIS-SOLAMIN | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2269126 | (17R,18R,21R,22S)-reticulation-1 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2269125 | (17S, 18S, 21S, 22R)-reticulation-1 | IC50 | = | 17.0 | nM | 7.77 |