Compound Detail
CHEMBL2269127
(10S)-COROSSOLINE Enter ChEMBL ID:
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CCCCCCCCCCCC[C@@H](O)[C@H]1CC[C@H]([C@H](O)CCCC[C@@H](O)CCCCCCCC2=C[C@H](C)OC2=O)O1
Basic Information
| ChEMBL ID | CHEMBL2269127 |
| Name | (10S)-COROSSOLINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GBNCDYGXXWZSAO-KTJZJERCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
580.9
MW (Da)
8.09
ALogP
6
HBA
3
HBD
96.2
PSA (Ų)
0.07
QED
2
Ro5 Violations
26
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NADH-ubiquinone oxidoreductase chain 1 CHEMBL4497 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NADH-ubiquinone oxidoreductase chain 1 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of Bos taurus (bovine) mitochodrial complex 1 isolated from heart sub... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/j.tet.2004.09.011 | NADH-ubiquinone oxidoreductase chain 1 | 1 |
Data from ChEMBL 36 via Core Engine