Assay Detail
Binding
CHEMBL3071480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PCP from nAChR in Torpedo nobiliana electric organs membranes by scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo nobiliana |
| Tissue | Electric organ |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit alpha (CHEMBL3097) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
Pharmacological Effects of Imidacloprid and Its Related Compounds on the Nicotinic Acetyicholine Receptor with Its Ion Channel from the Torpedo Electric Organ
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.07 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279676 | TENOCYCLIDINE | 2.0 | 1 | 5.74 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 5.50 |
| CHEMBL742 | KETAMINE | 4.0 | 1 | 4.96 |
| CHEMBL122270 | LOBELINE | 2.0 | 1 | 4.83 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.79 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 1 | 4.61 |
| CHEMBL1687 | — | — | 1 | - |
| CHEMBL1201329 | TRIMETHAPHAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279676 | TENOCYCLIDINE | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL742 | KETAMINE | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL122270 | LOBELINE | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1687 | — | IC50 | = | 1031000.0 | nM | - |
| CHEMBL1201329 | TRIMETHAPHAN | IC50 | > | 300000.0 | nM | - |