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Assay Detail

CHEMBL3073879

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Mus musculus (mouse) P388 cells assessed as growth inhibition
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Autocuration

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Computational QSAR models with high-dimensional descriptor selection improve antitumor activity design of ARC-111 analogues
Zhou W, Dai Z, Chen Y, Yuan Z
Med Chem Res (2013) 22 : 278 -286
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.92 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL191958 GENZ-644282 1.0 1 9.52
CHEMBL363340 1 9.15
CHEMBL70790 1 9.00
CHEMBL195107 1 9.00
CHEMBL195377 1 8.70
CHEMBL195805 1 8.52
CHEMBL540712 1 8.40
CHEMBL177804 1 8.40
CHEMBL191245 1 8.22
CHEMBL192411 1 8.22
CHEMBL363839 1 8.22
CHEMBL195332 1 8.22
CHEMBL191909 1 7.85
CHEMBL191032 1 7.80
CHEMBL370251 1 7.42
CHEMBL427002 1 7.30
CHEMBL195792 1 7.22
CHEMBL195611 1 6.70
CHEMBL192202 1 6.64
CHEMBL195102 1 6.64
CHEMBL195148 1 6.60
CHEMBL194932 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL191958 GENZ-644282 IC50 = 0.2999 nM 9.52
CHEMBL363340 IC50 = 0.6998 nM 9.15
CHEMBL70790 IC50 = 1.0 nM 9.00
CHEMBL195107 IC50 = 1.0 nM 9.00
CHEMBL195377 IC50 = 2.0 nM 8.70
CHEMBL195805 IC50 = 2.999 nM 8.52
CHEMBL540712 IC50 = 3.999 nM 8.40
CHEMBL177804 IC50 = 3.999 nM 8.40
CHEMBL191245 IC50 = 5.998 nM 8.22
CHEMBL192411 IC50 = 5.998 nM 8.22
CHEMBL363839 IC50 = 5.998 nM 8.22
CHEMBL195332 IC50 = 5.998 nM 8.22
CHEMBL191909 IC50 = 14.0 nM 7.85
CHEMBL191032 IC50 = 16.0 nM 7.80
CHEMBL370251 IC50 = 38.02 nM 7.42
CHEMBL427002 IC50 = 50.0 nM 7.30
CHEMBL195792 IC50 = 59.98 nM 7.22
CHEMBL195611 IC50 = 199.99 nM 6.70
CHEMBL192202 IC50 = 230.14 nM 6.64
CHEMBL195102 IC50 = 230.14 nM 6.64
CHEMBL195148 IC50 = 250.03 nM 6.60
CHEMBL194932 IC50 = 250.03 nM 6.60