Assay Detail
Binding
CHEMBL3074522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Myocardium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of benzofuran derivatives as ET receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.53 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296899 | — | — | 1 | 7.64 |
| CHEMBL314691 | BQ-123 | 2.0 | 1 | 7.55 |
| CHEMBL2296900 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296899 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL314691 | BQ-123 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2296900 | — | IC50 | = | 39.0 | nM | 7.41 |