Assay Detail
Functional
CHEMBL3074979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of parasite proliferation after 72 hr by Lilit Alamar Blue method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structureactivity relationship study of thiosemicarbazones on an African trypanosome: Trypanosoma brucei brucei
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.60 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2297585 | — | — | 1 | 5.40 |
| CHEMBL2297586 | — | — | 1 | 5.29 |
| CHEMBL162738 | — | — | 1 | 5.08 |
| CHEMBL1974077 | ACETONAPHTHONE-THIOSEMICARBAZONE | — | 1 | 5.02 |
| CHEMBL310957 | P-CHLOROPHENYL(METHYL)THIOSEMICARBAZONE | — | 1 | 4.96 |
| CHEMBL2297582 | — | — | 1 | 4.75 |
| CHEMBL258261 | — | — | 1 | 4.57 |
| CHEMBL2297580 | CARVONE-THIOSEMICARBAZONE | — | 1 | 4.40 |
| CHEMBL2297579 | — | — | 1 | 4.34 |
| CHEMBL1269809 | BENZOPHENONE-THIOSEMICARBAZONE | — | 1 | 4.17 |
| CHEMBL2297590 | — | — | 1 | 4.15 |
| CHEMBL388025 | CINNAMALDEHYDE THIOSEMICARBAZONE | — | 1 | 4.12 |
| CHEMBL2297594 | — | — | 1 | 4.08 |
| CHEMBL404699 | — | — | 1 | 4.04 |
| CHEMBL1341853 | — | — | 1 | - |
| CHEMBL2297583 | — | — | 1 | - |
| CHEMBL2297581 | — | — | 1 | - |
| CHEMBL2297600 | — | — | 1 | - |
| CHEMBL2297599 | — | — | 1 | - |
| CHEMBL2297598 | — | — | 1 | - |
| CHEMBL2297597 | — | — | 1 | - |
| CHEMBL2297596 | — | — | 1 | - |
| CHEMBL2297595 | — | — | 1 | - |
| CHEMBL2297593 | — | — | 1 | - |
| CHEMBL2297592 | — | — | 1 | - |
| CHEMBL2297591 | BENZALDEHYDE-THIOSEMICARBAZONE | — | 1 | - |
| CHEMBL2297587 | — | — | 1 | - |
| CHEMBL2297589 | — | — | 1 | - |
| CHEMBL256868 | ACETOPHENONE-THIOSEMICARBAZONE | — | 1 | - |
| CHEMBL2297588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2297585 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL2297586 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL162738 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL1974077 | ACETONAPHTHONE-THIOSEMICARBAZONE | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL310957 | P-CHLOROPHENYL(METHYL)THIOSEMICARBAZONE | IC50 | = | 11060.0 | nM | 4.96 |
| CHEMBL2297582 | — | IC50 | = | 17710.0 | nM | 4.75 |
| CHEMBL258261 | — | IC50 | = | 26890.0 | nM | 4.57 |
| CHEMBL2297580 | CARVONE-THIOSEMICARBAZONE | IC50 | = | 39710.0 | nM | 4.40 |
| CHEMBL2297579 | — | IC50 | = | 45580.0 | nM | 4.34 |
| CHEMBL1269809 | BENZOPHENONE-THIOSEMICARBAZONE | IC50 | = | 68340.0 | nM | 4.17 |
| CHEMBL2297590 | — | IC50 | = | 70400.0 | nM | 4.15 |
| CHEMBL388025 | CINNAMALDEHYDE THIOSEMICARBAZONE | IC50 | = | 76280.0 | nM | 4.12 |
| CHEMBL2297594 | — | IC50 | = | 82640.0 | nM | 4.08 |
| CHEMBL404699 | — | IC50 | = | 91140.0 | nM | 4.04 |
| CHEMBL2297584 | — | IC50 | - | — | - | |
| CHEMBL1341853 | — | IC50 | = | 146800.0 | nM | - |
| CHEMBL2297583 | — | IC50 | = | 135850.0 | nM | - |
| CHEMBL2297581 | — | IC50 | = | 260210.0 | nM | - |
| CHEMBL2297600 | — | IC50 | = | 292530.0 | nM | - |
| CHEMBL2297599 | — | IC50 | = | 170350.0 | nM | - |
| CHEMBL2297598 | — | IC50 | = | 221500.0 | nM | - |
| CHEMBL2297597 | — | IC50 | = | 123600.0 | nM | - |
| CHEMBL2297596 | — | IC50 | = | 132400.0 | nM | - |
| CHEMBL2297595 | — | IC50 | = | 258800.0 | nM | - |
| CHEMBL2297593 | — | IC50 | = | 163640.0 | nM | - |
| CHEMBL2297592 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL2297591 | BENZALDEHYDE-THIOSEMICARBAZONE | IC50 | = | 443540.0 | nM | - |
| CHEMBL2297587 | — | IC50 | - | — | - | |
| CHEMBL2297589 | — | IC50 | = | 199370.0 | nM | - |
| CHEMBL256868 | ACETOPHENONE-THIOSEMICARBAZONE | IC50 | = | 211880.0 | nM | - |
| CHEMBL2297588 | — | IC50 | - | — | - |