Compound Detail
CHEMBL310957
P-CHLOROPHENYL(METHYL)THIOSEMICARBAZONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL310957 |
| Name | P-CHLOROPHENYL(METHYL)THIOSEMICARBAZONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIGLNNLOFZKOCC-SDQBBNPISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
227.7
MW (Da)
2.31
ALogP
2
HBA
2
HBD
50.7
PSA (Ų)
0.35
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 4.96 | 4.96 | 11060.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | IC50 | = | 11060.0 | nM | 4.96 | Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream form ass... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8360870 | 10.1021/jm00068a001 | Mus musculus | 3 |
| 8360870 | 10.1021/jm00068a001 | Unchecked | 3 |
| 8360870 | 10.1021/jm00068a001 | Rattus norvegicus | 2 |
| - | 10.1007/s00044-012-0208-6 | Trypanosoma brucei brucei | 1 |
Data from ChEMBL 36 via Core Engine