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Assay Detail

CHEMBL3075554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of photosystem-mediated photosynthetic electron transport in Spinacia oleracea (spinach) leaf thylakoid assessed as reduction of oxygen evolution
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Spinacia oleracea
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome b6-f complex subunit 4 (CHEMBL2366461)
Type SINGLE PROTEIN
Organism Spinacia oleracea

Publication

Phytotoxicity Caused by Peroxidizing Herbicides Is Alleviated by 2-Substituted 4, 6-Bis(ethylamino)-1, 3, 5-triazines
OHKI A, OHKI S, KOIZUMI K, SATO Y, KOHNO H, BOGER P, WAKABAYASHI K
J Pestic Sci (1997) 22 : 309 -313
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 6.38 6.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278489 DCMU 1 6.93
CHEMBL1888800 SIMETRYN 1 6.93
CHEMBL2287129 1 6.69
CHEMBL2287128 1 6.67
CHEMBL1605837 SIMAZINE 1 6.28
CHEMBL2287127 1 4.75
CHEMBL2287126 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278489 DCMU IC50 = 117.49 nM 6.93
CHEMBL1888800 SIMETRYN IC50 = 117.49 nM 6.93
CHEMBL2287129 IC50 = 204.17 nM 6.69
CHEMBL2287128 IC50 = 213.8 nM 6.67
CHEMBL1605837 SIMAZINE IC50 = 524.81 nM 6.28
CHEMBL2287127 IC50 = 17782.79 nM 4.75
CHEMBL2287126 IC50 = 446683.59 nM -