Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL278489

DCMU
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL278489
Name DCMU
Phase Preclinical
Structure Type MOL
InChI Key XMTQQYYKAHVGBJ-UHFFFAOYSA-N
8
Targets
21
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

233.1
MW (Da)
3.09
ALogP
1
HBA
1
HBD
32.3
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C9H10Cl2N2O
MW 233.10
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -2.09

Activity Summary

IC50 21 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Photosystem II protein D1
CHEMBL2366481
 IC50 7.3 6.53 50.1 3
Cytochrome b6-f complex subunit 4
CHEMBL2366461
 IC50 6.93 6.93 117.5 1
Photosystem Q(B) protein
CHEMBL2366557
 IC50 6.89 6.645 130.0 2
Unchecked
CHEMBL612545
 IC50 6.85 6.0617 140.0 6
Protoporphyrinogen IX oxidase
CHEMBL2366515
 IC50 6.47 6.47 338.8 1
Photosystem II protein D1
CHEMBL2366463
 IC50 5.8 5.8 1584.9 1
Spinacia oleracea
CHEMBL612824
 IC50 5.72 5.72 1900.0 2
Chlorella vulgaris
CHEMBL613342
 IC50 5.14 5.14 7300.0 5

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Photosystem II protein D1 IC50 = 50.12 nM 7.3 Inhibition of photosystem II mediated electron transport in Spinacia oleracea (s... -
Cytochrome b6-f complex subunit 4 IC50 = 117.49 nM 6.93 Inhibition of photosystem-mediated photosynthetic electron transport in Spinacia... -
Photosystem Q(B) protein IC50 = 130.0 nM 6.89 Inhibition ofphotosystem II in s-triazine-susceptible Poa annua leaf thylakoid m... -
Unchecked IC50 = 140.0 nM 6.85 Inhibition of photosynthetic phosphorylation from water to methyl viologen in sp... 11076561
Unchecked IC50 = 230.0 nM 6.64 Inhibition of Photosystem 2 in spinach thylakoid membrane assessed as inhibition... 12542343
Photosystem II protein D1 IC50 = 269.77 nM 6.57 Inhibition of photosynthetic electron transport at the PSII level in intact chlo... 15884806
Protoporphyrinogen IX oxidase IC50 = 338.84 nM 6.47 Inhibition of photosystem-mediated photosynthetic electron transport in Scenedes... -
Photosystem Q(B) protein IC50 = 400.0 nM 6.4 Inhibition of photosystem II in s-triazine-resistant Poa annua leaf thylakoid me... -
Photosystem II protein D1 IC50 = 1584.89 nM 5.8 Inhibition of photosystem II mediated electron transport in Marchantia polymorph... -
Unchecked IC50 = 1900.0 nM 5.72 Inhibition of photosynthesis in spinach chloroplast 17142046
Unchecked IC50 = 1900.0 nM 5.72 Inhibition of PS2 in spinach chloroplasts assessed as photoreduction of DCPIP in... 24075143
Photosystem II protein D1 IC50 = 1900.0 nM 5.72 Inhibition of photosystem II in Spinacia oleracea (spinach) chloroplasts assesse... 21724391
Spinacia oleracea IC50 = 1900.0 nM 5.72 Inhibition of photosynthetic electron transport in Spinacia oleracea (spinach) c... 18259145
Unchecked IC50 = 1900.0 nM 5.72 Inhibition of photosynthetic electron transport in Spinacia oleracea chloroplast... 17870211
Spinacia oleracea IC50 = 1900.0 nM 5.72 Herbicidal activity in Spinacia oleracea assessed as inhibition of photosyntheti... 18342517
Unchecked IC50 = 1900.0 nM 5.72 Inhibition of oxygen evolution rate in spinach chloroplasts 17449247
Chlorella vulgaris IC50 = 7300.0 nM 5.14 Antialgal activity against Chlorella vulgaris assessed as inhibition of chloroph... 17449247
Chlorella vulgaris IC50 = 7300.0 nM 5.14 Inhibition of Chlorella vulgaris Beij assessed as reduction of chlorophyll conte... 17142046
Chlorella vulgaris IC50 = 7300.0 nM 5.14 Herbicidal activity against Chlorella vulgaris Beij assessed as decrease in chlo... 18342517
Chlorella vulgaris IC50 = 7300.0 nM 5.14 Antialagal activity against Chlorella vulgaris Beji assessed as reduction in chl... 17870211

Literature References

PubMed DOI Target Context # Activities
- 10.1584/jpestics.26.236 Poa annua 11
- 10.1584/jpestics.22.309 Scenedesmus acutus 10
17927149 10.1021/jf072120x Auxenochlorella protothecoides 4
- 10.1016/j.cropro.2008.08.012 Erigeron canadensis 3
- 10.1584/jpestics.26.236 Photosystem Q(B) protein 3
17927149 10.1021/jf072120x Unchecked 2
- 10.1271/bbb.57.1389 Photosystem II protein D1 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
18338868 10.1021/jf072964g Spinacia oleracea 2
20739103 10.1016/j.ejmech.2010.07.050 Saccharomyces cerevisiae 2
20739103 10.1016/j.ejmech.2010.07.050 Unchecked 2
12542343 10.1021/np0203842 Unchecked 1
18646760 10.1021/jf8010432 Spinacia oleracea 1
18616221 10.1021/np070647y Unchecked 1
17870211 10.1016/j.ejmech.2007.07.013 Unchecked 1
18342517 10.1016/j.bmc.2008.02.065 Chlorella vulgaris 1
11076561 10.1021/np0001326 Unchecked 1
17142046 10.1016/j.bmc.2006.11.020 Chlorella vulgaris 1
17142046 10.1016/j.bmc.2006.11.020 Unchecked 1
17449247 10.1016/j.bmcl.2007.04.007 Unchecked 1

Data from ChEMBL 36 via Core Engine