Assay Detail
Functional
CHEMBL3075717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vaccinia virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-<i>N</i>-substituted-hydrazinecarbothioamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 4.78 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.00 |
| CHEMBL2296648 | — | — | 1 | 4.96 |
| CHEMBL2296654 | — | — | 1 | 4.70 |
| CHEMBL2296653 | — | — | 1 | 4.70 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.54 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL2296652 | — | — | 1 | - |
| CHEMBL2296651 | — | — | 1 | - |
| CHEMBL2296650 | — | — | 1 | - |
| CHEMBL2296649 | — | — | 1 | - |
| CHEMBL2296647 | — | — | 1 | - |
| CHEMBL2296646 | — | — | 1 | - |
| CHEMBL2296655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2296648 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2296654 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2296653 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL184 | ACYCLOVIR | EC50 | > | 250000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | > | 100000.0 | nM | - |
| CHEMBL2296652 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296651 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296650 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296649 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296647 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296646 | — | EC50 | >= | 20000.0 | nM | - |
| CHEMBL2296655 | — | EC50 | > | 100000.0 | nM | - |