Assay Detail
Binding
CHEMBL3075829
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Inhibition of AchE in Rattus norvegicus (rat) cortex homogenates by Ellman's method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.29 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2299049 | — | — | 1 | 8.00 |
| CHEMBL2299048 | — | — | 1 | 7.89 |
| CHEMBL2299047 | — | — | 1 | 7.79 |
| CHEMBL2299035 | — | — | 1 | 7.74 |
| CHEMBL2299046 | — | — | 1 | 7.73 |
| CHEMBL2299045 | — | — | 1 | 7.71 |
| CHEMBL2299226 | — | — | 1 | 7.71 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.67 |
| CHEMBL2299044 | — | — | 1 | 7.67 |
| CHEMBL2299225 | — | — | 1 | 7.66 |
| CHEMBL2299224 | — | — | 1 | 7.56 |
| CHEMBL2299036 | — | — | 1 | 7.52 |
| CHEMBL2299223 | — | — | 1 | 7.43 |
| CHEMBL2299222 | — | — | 1 | 7.41 |
| CHEMBL2299221 | — | — | 1 | 7.40 |
| CHEMBL2299042 | — | — | 1 | 6.97 |
| CHEMBL2299041 | — | — | 1 | 6.95 |
| CHEMBL2299043 | — | — | 1 | 6.94 |
| CHEMBL2299040 | — | — | 1 | 6.94 |
| CHEMBL2299039 | — | — | 1 | 6.93 |
| CHEMBL2299037 | — | — | 1 | 6.92 |
| CHEMBL2299038 | — | — | 1 | 6.92 |
| CHEMBL2299051 | — | — | 1 | 6.88 |
| CHEMBL502107 | — | — | 1 | 6.86 |
| CHEMBL2299050 | — | — | 1 | 6.85 |
| CHEMBL2299052 | — | — | 1 | 6.84 |
| CHEMBL73933 | 4'-HYDROXY-FLAVANONE | — | 1 | 6.84 |
| CHEMBL485021 | 3'-HYDROXYFLAVANONE | — | 1 | 6.83 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2299049 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL2299048 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL2299047 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL2299035 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2299046 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL2299045 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL2299226 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL2299044 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL2299225 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL2299224 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL2299036 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL2299223 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL2299222 | — | IC50 | = | 38.8 | nM | 7.41 |
| CHEMBL2299221 | — | IC50 | = | 39.9 | nM | 7.40 |
| CHEMBL2299042 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL2299041 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL2299043 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL2299040 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2299039 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2299037 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2299038 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL2299051 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL502107 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL2299050 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2299052 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL73933 | 4'-HYDROXY-FLAVANONE | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL485021 | 3'-HYDROXYFLAVANONE | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | IC50 | = | 149.0 | nM | 6.83 |