Assay Detail
Binding
CHEMBL3082113
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Inhibition of Sus scrofa (pig) carboxylesterase isolated from liver in using p-nitrophenyl acetate as substrate incubated for 5 min prior to substrate addition measured for 2 min by spectrophotometric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.29 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89506 | — | — | 1 | 7.43 |
| CHEMBL440542 | — | — | 1 | 7.26 |
| CHEMBL460809 | — | — | 1 | 7.12 |
| CHEMBL270375 | — | — | 1 | 6.92 |
| CHEMBL270374 | — | — | 1 | 6.87 |
| CHEMBL467450 | — | — | 1 | 6.33 |
| CHEMBL467451 | — | — | 1 | 5.85 |
| CHEMBL2268509 | — | — | 1 | 5.47 |
| CHEMBL460807 | — | — | 1 | 5.25 |
| CHEMBL449775 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89506 | — | IC50 | = | 36.8 | nM | 7.43 |
| CHEMBL440542 | — | IC50 | = | 54.3 | nM | 7.26 |
| CHEMBL460809 | — | IC50 | = | 75.3 | nM | 7.12 |
| CHEMBL270375 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL270374 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL467450 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL467451 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL2268509 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL460807 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL449775 | — | IC50 | = | 39000.0 | nM | 4.41 |