Assay Detail
Functional
CHEMBL3083974
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Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) left atrium measured after 60 min by isometric transducer analysis in absence of benextramine/4-DAMP mustard
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polyamines May Modulate Both G Protein-Coupled Receptors and G Proteins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.20 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | — | 1 | 9.70 |
| CHEMBL104845 | N-DODECYL LYSINE AMIDE | — | 1 | 9.38 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL104845 | N-DODECYL LYSINE AMIDE | EC50 | = | 0.4169 | nM | 9.38 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | EC50 | = | 3.09 | nM | 8.51 |