Compound Detail
CHEMBL104845
N-DODECYL LYSINE AMIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL104845 |
| Name | N-DODECYL LYSINE AMIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKFORZPFABJQKU-KRWDZBQOSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
313.5
MW (Da)
3.48
ALogP
3
HBA
3
HBD
81.1
PSA (Ų)
0.38
QED
0
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 9.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Right atrium CHEMBL2367363 | EC50 | 9.55 | 9.465 | 0.3 | 2 |
| Left atrium CHEMBL2367407 | EC50 | 9.44 | 9.41 | 0.4 | 2 |
| HL-60 CHEMBL383 | EC50 | 6.1 | 6.1 | 794.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Right atrium | EC50 | = | 0.2818 | nM | 9.55 | Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) ... | - |
| Left atrium | EC50 | = | 0.3631 | nM | 9.44 | Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) ... | - |
| Right atrium | EC50 | = | 0.4169 | nM | 9.38 | Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) ... | - |
| Left atrium | EC50 | = | 0.4169 | nM | 9.38 | Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) ... | - |
| HL-60 | EC50 | = | 794.33 | nM | 6.1 | -log of the half-maximal concentration for stimulation of GTPase in HL-60 membra... | 9301677 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9301677 | 10.1021/jm9703092 | HL-60 | 2 |
| - | 10.1007/s00044-004-0010-1 | Right atrium | 2 |
| - | 10.1007/s00044-004-0010-1 | Left atrium | 2 |
Data from ChEMBL 36 via Core Engine