Assay Detail
Functional
CHEMBL688385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
-log of the half-maximal concentration for stimulation of GTPase in HL-60 membrane (sensitive to PTX)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Alkyl-substituted amino acid amides and analogous di- and triamines: new non-peptide G protein activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.23 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106781 | — | — | 1 | 6.60 |
| CHEMBL104187 | — | — | 1 | 6.60 |
| CHEMBL107253 | — | — | 1 | 6.30 |
| CHEMBL106687 | LYCETAMINE | -1.0 | 1 | 6.30 |
| CHEMBL106881 | — | — | 1 | 6.30 |
| CHEMBL104845 | N-DODECYL LYSINE AMIDE | — | 1 | 6.10 |
| CHEMBL422780 | — | — | 1 | 6.10 |
| CHEMBL2370408 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106781 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL104187 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL107253 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL106687 | LYCETAMINE | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL106881 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL104845 | N-DODECYL LYSINE AMIDE | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL422780 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL2370408 | — | EC50 | = | 3162.28 | nM | 5.50 |