Assay Detail
Functional
CHEMBL3090541
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Ex-vivo inhibition of PrCP in plasma of po dosed C57 mouse after 20 hrs by FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086040 | — | — | 1 | 8.96 |
| CHEMBL3086028 | — | — | 1 | 7.72 |
| CHEMBL3086036 | — | — | 1 | 7.15 |
| CHEMBL3086041 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086040 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3086028 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3086036 | — | Ki | = | 70.5 | nM | 7.15 |
| CHEMBL3086041 | — | Ki | = | 158.0 | nM | 6.80 |