Assay Detail
Functional
CHEMBL3090697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) harboring wild type M2 channel infected in MDCK cells assessed as reduction of cytopathic effect after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.05 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 6.92 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.09 |
| CHEMBL3088164 | — | — | 1 | 5.14 |
| CHEMBL3088166 | — | — | 1 | - |
| CHEMBL3088292 | — | — | 1 | - |
| CHEMBL3088169 | — | — | 1 | - |
| CHEMBL3088168 | — | — | 1 | - |
| CHEMBL3088167 | — | — | 1 | - |
| CHEMBL3088165 | — | — | 1 | - |
| CHEMBL3088163 | — | — | 1 | - |
| CHEMBL3088162 | — | — | 1 | - |
| CHEMBL3088161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL660 | AMANTADINE | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3088164 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3088166 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3088292 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088169 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088168 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088167 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088165 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088163 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088162 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3088161 | — | EC50 | > | 100000.0 | nM | - |