Assay Detail
Binding
CHEMBL3090744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus Udorn/72 M2 ion channel V27A mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltage clamp assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.26 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3088292 | — | — | 1 | 6.54 |
| CHEMBL3088163 | — | — | 1 | 4.94 |
| CHEMBL3088168 | — | — | 1 | 4.86 |
| CHEMBL3088169 | — | — | 1 | 4.69 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | - |
| CHEMBL3088167 | — | — | 1 | - |
| CHEMBL3088166 | — | — | 1 | - |
| CHEMBL3088165 | — | — | 1 | - |
| CHEMBL3088164 | — | — | 1 | - |
| CHEMBL3088162 | — | — | 1 | - |
| CHEMBL3088161 | — | — | 1 | - |
| CHEMBL1789740 | — | — | 1 | - |
| CHEMBL1789779 | — | — | 1 | - |
| CHEMBL1789811 | — | — | 1 | - |
| CHEMBL1789771 | — | — | 1 | - |
| CHEMBL508777 | — | — | 1 | - |
| CHEMBL450375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3088292 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3088163 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3088168 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3088169 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL660 | AMANTADINE | IC50 | - | — | - | |
| CHEMBL3088167 | — | IC50 | - | — | - | |
| CHEMBL3088166 | — | IC50 | - | — | - | |
| CHEMBL3088165 | — | IC50 | - | — | - | |
| CHEMBL3088164 | — | IC50 | - | — | - | |
| CHEMBL3088162 | — | IC50 | - | — | - | |
| CHEMBL3088161 | — | IC50 | - | — | - | |
| CHEMBL1789740 | — | IC50 | - | — | - | |
| CHEMBL1789779 | — | IC50 | - | — | - | |
| CHEMBL1789811 | — | IC50 | - | — | - | |
| CHEMBL1789771 | — | IC50 | - | — | - | |
| CHEMBL508777 | — | IC50 | - | — | - | |
| CHEMBL450375 | — | IC50 | - | — | - |