Assay Detail
Binding
CHEMBL3090995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus M2 ion channel S31N mutant by two-electrode voltage clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.63 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3088160 | — | — | 1 | 4.80 |
| CHEMBL2324172 | — | — | 1 | 4.45 |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | - |
| CHEMBL3088159 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3088160 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2324172 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL959 | RIMANTADINE | IC50 | > | 500000.0 | nM | - |
| CHEMBL3088159 | — | IC50 | > | 100000.0 | nM | - |