Assay Detail
Binding
CHEMBL3094810
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Inhibition of horse serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.33 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093177 | — | — | 1 | 8.21 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.72 |
| CHEMBL3093173 | — | — | 1 | 7.63 |
| CHEMBL3093170 | — | — | 1 | 7.59 |
| CHEMBL3093172 | — | — | 1 | 7.56 |
| CHEMBL3093167 | — | — | 1 | 7.52 |
| CHEMBL3093176 | — | — | 1 | 7.51 |
| CHEMBL3093174 | — | — | 1 | 7.48 |
| CHEMBL3093168 | — | — | 1 | 7.46 |
| CHEMBL3093180 | — | — | 1 | 7.36 |
| CHEMBL3093181 | — | — | 1 | 7.35 |
| CHEMBL3093166 | — | — | 1 | 7.33 |
| CHEMBL3093179 | — | — | 1 | 7.26 |
| CHEMBL3093178 | — | — | 1 | 7.18 |
| CHEMBL3093175 | — | — | 1 | 7.03 |
| CHEMBL3093169 | — | — | 1 | 6.96 |
| CHEMBL3093165 | — | — | 1 | 6.63 |
| CHEMBL3093171 | — | — | 1 | 6.21 |
| CHEMBL450675 | BONDUCELLIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093177 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL95 | TACRINE | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL3093173 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL3093170 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL3093172 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL3093167 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL3093176 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL3093174 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3093168 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL3093180 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL3093181 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL3093166 | — | IC50 | = | 47.1 | nM | 7.33 |
| CHEMBL3093179 | — | IC50 | = | 54.6 | nM | 7.26 |
| CHEMBL3093178 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL3093175 | — | IC50 | = | 93.1 | nM | 7.03 |
| CHEMBL3093169 | — | IC50 | = | 108.8 | nM | 6.96 |
| CHEMBL3093165 | — | IC50 | = | 235.2 | nM | 6.63 |
| CHEMBL3093171 | — | IC50 | = | 612.5 | nM | 6.21 |
| CHEMBL450675 | BONDUCELLIN | IC50 | > | 100000.0 | nM | - |