Assay Detail
Binding
CHEMBL3095597
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Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.99 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093791 | — | — | 1 | 8.55 |
| CHEMBL32823 | — | — | 1 | 8.39 |
| CHEMBL3093787 | — | — | 1 | 8.36 |
| CHEMBL3093786 | — | — | 1 | 8.35 |
| CHEMBL3093785 | — | — | 1 | 8.31 |
| CHEMBL3093788 | — | — | 1 | 7.86 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.80 |
| CHEMBL3093789 | — | — | 1 | 7.78 |
| CHEMBL3093790 | — | — | 1 | 7.59 |
| CHEMBL3093793 | — | — | 1 | 7.54 |
| CHEMBL3093792 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093791 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL32823 | — | IC50 | = | 4.08 | nM | 8.39 |
| CHEMBL3093787 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL3093786 | — | IC50 | = | 4.52 | nM | 8.35 |
| CHEMBL3093785 | — | IC50 | = | 4.94 | nM | 8.31 |
| CHEMBL3093788 | — | IC50 | = | 13.97 | nM | 7.86 |
| CHEMBL95 | TACRINE | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL3093789 | — | IC50 | = | 16.55 | nM | 7.78 |
| CHEMBL3093790 | — | IC50 | = | 25.77 | nM | 7.59 |
| CHEMBL3093793 | — | IC50 | = | 28.53 | nM | 7.54 |
| CHEMBL3093792 | — | IC50 | = | 38.88 | nM | 7.41 |