Assay Detail
Binding
CHEMBL3096089
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Binding affinity to rat adenosine A2A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.93 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413079 | — | — | 1 | 8.10 |
| CHEMBL3093328 | — | — | 1 | 6.83 |
| CHEMBL3093327 | — | — | 1 | 6.26 |
| CHEMBL282038 | — | — | 1 | 5.25 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.66 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413079 | — | Ki | = | 8.04 | nM | 8.10 |
| CHEMBL3093328 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL3093327 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL282038 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL113 | CAFFEINE | Ki | = | 32500.0 | nM | 4.49 |