Assay Detail

CHEMBL3096676

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Functional

Cytotoxicity against human A2780 cells after 24 hrs by clonogenic assay

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

Open DB target context

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A2780 (CHEMBL614004) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Autocuration

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.

Christensen MK, Erichsen KD, Olesen UH, Tjørnelund J, Fristrup P, Thougaard A, Nielsen SJ, Sehested M, Jensen PB, Loza E, Kalvinsh I, Garten A, Kiess W, Björkling F.
J Med Chem (2013) 56 : 9071 -9088
PubMed 24164086 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.26	9.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3094255	—	—	1	9.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3094255	—	IC50	=	0.55	nM	9.26