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Assay Detail

CHEMBL3096866

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by WST-1 assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Autocuration

Target

A2780 (CHEMBL614004) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
Christensen MK, Erichsen KD, Olesen UH, Tjørnelund J, Fristrup P, Thougaard A, Nielsen SJ, Sehested M, Jensen PB, Loza E, Kalvinsh I, Garten A, Kiess W, Björkling F.
J Med Chem (2013) 56 : 9071 -9088
PubMed 24164086 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 9.42 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3094251 — — 1 11.00
CHEMBL3094260 — — 1 10.96
CHEMBL3094264 — — 1 10.66
CHEMBL3094255 — — 1 10.60
CHEMBL3094223 — — 1 10.52
CHEMBL3094262 — — 1 10.31
CHEMBL3094257 — — 1 10.28
CHEMBL3094218 — — 1 10.28
CHEMBL2417795 — — 1 10.26
CHEMBL3094219 — — 1 10.10
CHEMBL3094252 — — 1 10.09
CHEMBL3094259 — — 1 10.05
CHEMBL3094263 — — 1 10.04
CHEMBL3094250 — — 1 10.00
CHEMBL3094258 — — 1 9.80
CHEMBL3094254 — — 1 9.80
CHEMBL3094248 — — 1 9.80
CHEMBL3094238 — — 1 9.77
CHEMBL3094232 — — 1 9.70
CHEMBL3094222 — — 1 9.66
CHEMBL3094234 — — 1 9.60
CHEMBL3094235 — — 1 9.57
CHEMBL3094225 — — 1 9.54
CHEMBL3094242 — — 1 9.51
CHEMBL3094221 — — 1 9.49
CHEMBL3094233 — — 1 9.42
CHEMBL3094229 — — 1 9.31
CHEMBL3094228 — — 1 9.31
CHEMBL3094256 — — 1 9.29
CHEMBL17289 CHS-828 1.0 1 9.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3094251 — IC50 = 0.01 nM 11.00
CHEMBL3094260 — IC50 = 0.011 nM 10.96
CHEMBL3094264 — IC50 = 0.022 nM 10.66
CHEMBL3094255 — IC50 = 0.025 nM 10.60
CHEMBL3094223 — IC50 = 0.03 nM 10.52
CHEMBL3094262 — IC50 = 0.049 nM 10.31
CHEMBL3094257 — IC50 = 0.052 nM 10.28
CHEMBL3094218 — IC50 = 0.053 nM 10.28
CHEMBL2417795 — IC50 = 0.055 nM 10.26
CHEMBL3094219 — IC50 = 0.08 nM 10.10
CHEMBL3094252 — IC50 = 0.081 nM 10.09
CHEMBL3094259 — IC50 = 0.089 nM 10.05
CHEMBL3094263 — IC50 = 0.091 nM 10.04
CHEMBL3094250 — IC50 = 0.1 nM 10.00
CHEMBL3094248 — IC50 = 0.16 nM 9.80
CHEMBL3094254 — IC50 = 0.16 nM 9.80
CHEMBL3094258 — IC50 = 0.16 nM 9.80
CHEMBL3094238 — IC50 = 0.17 nM 9.77
CHEMBL3094232 — IC50 = 0.2 nM 9.70
CHEMBL3094222 — IC50 = 0.22 nM 9.66
CHEMBL3094234 — IC50 = 0.25 nM 9.60
CHEMBL3094235 — IC50 = 0.27 nM 9.57
CHEMBL3094225 — IC50 = 0.29 nM 9.54
CHEMBL3094242 — IC50 = 0.31 nM 9.51
CHEMBL3094221 — IC50 = 0.32 nM 9.49
CHEMBL3094233 — IC50 = 0.38 nM 9.42
CHEMBL3094228 — IC50 = 0.49 nM 9.31
CHEMBL3094229 — IC50 = 0.49 nM 9.31
CHEMBL3094256 — IC50 = 0.51 nM 9.29
CHEMBL17289 CHS-828 IC50 = 0.56 nM 9.25
CHEMBL3094237 — IC50 = 0.56 nM 9.25
CHEMBL3094243 — IC50 = 0.58 nM 9.24
CHEMBL3094230 — IC50 = 0.57 nM 9.24
CHEMBL3094231 — IC50 = 0.59 nM 9.23
CHEMBL3094226 — IC50 = 0.68 nM 9.17
CHEMBL3094227 — IC50 = 0.73 nM 9.14
CHEMBL3094236 — IC50 = 0.91 nM 9.04
CHEMBL566757 DAPORINAD IC50 = 1.6 nM 8.80
CHEMBL3094245 — IC50 = 1.7 nM 8.77
CHEMBL3094240 — IC50 = 1.8 nM 8.74
CHEMBL3094244 — IC50 = 2.2 nM 8.66
CHEMBL3094247 — IC50 = 2.7 nM 8.57
CHEMBL3094239 — IC50 = 3.4 nM 8.47
CHEMBL3094220 — IC50 = 3.9 nM 8.41
CHEMBL3094224 — IC50 = 4.1 nM 8.39
CHEMBL3094241 — IC50 = 4.6 nM 8.34
CHEMBL3094246 — IC50 = 13.0 nM 7.89
CHEMBL3094249 — IC50 = 35.0 nM 7.46
CHEMBL3094253 — IC50 = 98.0 nM 7.01
CHEMBL3094261 — IC50 = 0.0041 nM -