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Assay Detail

CHEMBL3096875

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Functional
Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.
Pandit B, Hu Z, Chettiar SN, Zink J, Xiao Z, Etter JP, Bhasin D, Li PK.
Bioorg Med Chem Lett (2013) 23 : 6902 -6904
PubMed 24169233 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.92 5.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90558 1 5.41
CHEMBL313952 1 5.24
CHEMBL249394 1 5.18
CHEMBL89081 1 5.15
CHEMBL89868 1 5.09
CHEMBL248786 1 5.04
CHEMBL399744 1 4.85
CHEMBL91130 1 4.82
CHEMBL248589 1 4.61
CHEMBL88953 1 4.34
CHEMBL88474 1 4.34
CHEMBL424612 1 -
CHEMBL90616 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90558 IC50 = 3940.0 nM 5.41
CHEMBL313952 IC50 = 5740.0 nM 5.24
CHEMBL249394 IC50 = 6620.0 nM 5.18
CHEMBL89081 IC50 = 7120.0 nM 5.15
CHEMBL89868 IC50 = 8140.0 nM 5.09
CHEMBL248786 IC50 = 9160.0 nM 5.04
CHEMBL399744 IC50 = 14120.0 nM 4.85
CHEMBL91130 IC50 = 15030.0 nM 4.82
CHEMBL248589 IC50 = 24620.0 nM 4.61
CHEMBL88953 IC50 = 45900.0 nM 4.34
CHEMBL88474 IC50 = 45620.0 nM 4.34
CHEMBL424612 IC50 > 50000.0 nM -
CHEMBL90616 IC50 > 50000.0 nM -