Assay Detail
Binding
CHEMBL3097097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](-)-sulpiride from dopamine D2 receptor in rat brain after 120 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.56 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093268 | — | — | 1 | 7.17 |
| CHEMBL3093270 | — | — | 1 | 7.11 |
| CHEMBL325262 | — | — | 1 | 6.89 |
| CHEMBL113621 | — | — | 1 | 6.49 |
| CHEMBL112125 | — | — | 1 | 6.18 |
| CHEMBL3093269 | — | — | 1 | 6.08 |
| CHEMBL145867 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093268 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL3093270 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL325262 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL113621 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL112125 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL3093269 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL145867 | — | Ki | = | 940.0 | nM | 6.03 |