Assay Detail
Binding
CHEMBL3097103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain after 120 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.76 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112125 | — | — | 1 | 9.92 |
| CHEMBL3093268 | — | — | 1 | 9.82 |
| CHEMBL3093270 | — | — | 1 | 9.25 |
| CHEMBL3093269 | — | — | 1 | 8.73 |
| CHEMBL325262 | — | — | 1 | 8.31 |
| CHEMBL113621 | — | — | 1 | 8.19 |
| CHEMBL145867 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112125 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL3093268 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3093270 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL3093269 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL325262 | — | Ki | = | 4.93 | nM | 8.31 |
| CHEMBL113621 | — | Ki | = | 6.47 | nM | 8.19 |
| CHEMBL145867 | — | Ki | = | 82.0 | nM | 7.09 |