Assay Detail
Binding
CHEMBL3097310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from SERT in rat cortical membranes after 6 mins by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.52 |
| CHEMBL3092348 | — | — | 1 | 7.89 |
| CHEMBL3092343 | — | — | 1 | 7.85 |
| CHEMBL3092342 | — | — | 1 | 7.58 |
| CHEMBL3092347 | — | — | 1 | 7.43 |
| CHEMBL3092346 | — | — | 1 | 7.41 |
| CHEMBL3092344 | — | — | 1 | 7.37 |
| CHEMBL3092345 | — | — | 1 | 7.21 |
| CHEMBL3092350 | — | — | 1 | 7.06 |
| CHEMBL3092349 | — | — | 1 | 7.01 |
| CHEMBL3092351 | — | — | 1 | 6.86 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3092348 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3092343 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3092342 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3092347 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3092346 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3092344 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3092345 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3092350 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3092349 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3092351 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL56 | 8-OH-DPAT | IC50 | - | — | - |