Assay Detail
Binding
CHEMBL3100232
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Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.51 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.16 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.10 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.82 |
| CHEMBL117 | CHRYSIN | — | 1 | 4.41 |
| CHEMBL3100124 | — | — | 1 | 4.05 |
| CHEMBL3100127 | — | — | 1 | - |
| CHEMBL3100125 | — | — | 1 | - |
| CHEMBL3100129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL117 | CHRYSIN | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL3100124 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3100127 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3100125 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL3100129 | — | IC50 | = | 118000.0 | nM | - |