Assay Detail
Functional
CHEMBL3100992
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Antiproliferative activity against human A2780 cells after 72 hrs by sulforhodamine B assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.88 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098518 | — | — | 1 | 8.74 |
| CHEMBL3098609 | — | — | 1 | 8.66 |
| CHEMBL3098608 | — | — | 1 | 8.54 |
| CHEMBL3098610 | — | — | 1 | 8.47 |
| CHEMBL3098517 | — | — | 1 | 8.43 |
| CHEMBL3098510 | — | — | 1 | 8.01 |
| CHEMBL3098611 | — | — | 1 | 7.85 |
| CHEMBL3098515 | — | — | 1 | 7.83 |
| CHEMBL2419503 | — | — | 1 | 7.75 |
| CHEMBL3098512 | — | — | 1 | 7.52 |
| CHEMBL3098511 | — | — | 1 | 7.30 |
| CHEMBL3098513 | — | — | 1 | 6.76 |
| CHEMBL3098514 | — | — | 1 | 6.58 |
| CHEMBL3098516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098518 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3098609 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3098608 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3098610 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3098517 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3098510 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3098611 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3098515 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL2419503 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3098512 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3098511 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3098513 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3098514 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL3098516 | — | IC50 | > | 2000.0 | nM | - |