Assay Detail
Functional
CHEMBL3101586
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Antiproliferative activity against human K562 cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
NAD-based inhibitors with anticancer potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.29 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098189 | — | — | 1 | 6.40 |
| CHEMBL3098187 | — | — | 1 | 6.30 |
| CHEMBL3098180 | — | — | 1 | 6.30 |
| CHEMBL3098190 | — | — | 1 | 6.10 |
| CHEMBL392204 | — | — | 1 | 6.00 |
| CHEMBL3098188 | — | — | 1 | 6.00 |
| CHEMBL3098191 | — | — | 1 | 5.82 |
| CHEMBL3098181 | — | — | 1 | 5.80 |
| CHEMBL3098178 | — | — | 1 | 5.60 |
| CHEMBL3098174 | — | — | 1 | 5.52 |
| CHEMBL3098192 | — | — | 1 | 5.52 |
| CHEMBL3098172 | — | — | 1 | 5.38 |
| CHEMBL410744 | — | — | 1 | 5.24 |
| CHEMBL3098164 | — | — | 1 | 5.21 |
| CHEMBL3098170 | — | — | 1 | 5.17 |
| CHEMBL2437261 | — | — | 1 | 5.08 |
| CHEMBL2437269 | — | — | 1 | 5.00 |
| CHEMBL3098167 | — | — | 1 | 4.85 |
| CHEMBL2437258 | — | — | 1 | 4.80 |
| CHEMBL2437266 | — | — | 1 | 4.54 |
| CHEMBL2437262 | — | — | 1 | 4.54 |
| CHEMBL3098179 | — | — | 1 | 4.32 |
| CHEMBL3098182 | — | — | 1 | 4.31 |
| CHEMBL2437265 | — | — | 1 | 4.30 |
| CHEMBL2437272 | — | — | 1 | 4.26 |
| CHEMBL3098177 | — | — | 1 | - |
| CHEMBL3098175 | — | — | 1 | - |
| CHEMBL3098173 | — | — | 1 | - |
| CHEMBL3098171 | — | — | 1 | - |
| CHEMBL3098186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098189 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3098187 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3098180 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3098190 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL392204 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3098188 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3098191 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3098181 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3098178 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3098174 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3098192 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3098172 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL410744 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3098164 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3098170 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2437261 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2437269 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3098167 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2437258 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2437262 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2437266 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3098179 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3098182 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL2437265 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2437272 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3098183 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098184 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2437255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098185 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2437273 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2437254 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098168 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098186 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098173 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3098177 | — | IC50 | > | 100000.0 | nM | - |