Assay Detail
Binding
CHEMBL3101628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at wild type TGR5 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G-protein coupled bile acid receptor 1 (CHEMBL5409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Probing the Binding Site of Bile Acids in TGR5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.91 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566315 | OBETICHOLIC ACID | 4.0 | 1 | 7.00 |
| CHEMBL567640 | — | — | 1 | 6.75 |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | 6.14 |
| CHEMBL3098607 | — | — | 1 | 5.88 |
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 4.99 |
| CHEMBL205596 | CHOLIC ACID | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566315 | OBETICHOLIC ACID | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL567640 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1478 | LITHOCHOLIC ACID | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3098607 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL240597 | CHENODIOL | EC50 | = | 10290.0 | nM | 4.99 |
| CHEMBL205596 | CHOLIC ACID | EC50 | = | 19830.0 | nM | 4.70 |