Assay Detail
Functional
CHEMBL3102680
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Antiinflammatory activity in RBL2H3 cells assessed as inhibition of degranulation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of licochalcone analogues with increased anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.69 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139702 | LICOAGROCHACONE A | — | 1 | 4.77 |
| CHEMBL1644932 | LICOCHALCONE D | — | 1 | 4.68 |
| CHEMBL141207 | — | — | 1 | 4.62 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | - |
| CHEMBL141530 | ECHINATIN | — | 1 | - |
| CHEMBL2437372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139702 | LICOAGROCHACONE A | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1644932 | LICOCHALCONE D | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL141207 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL141530 | ECHINATIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL2437372 | — | IC50 | > | 30000.0 | nM | - |