Compound Detail
CHEMBL1644932
LICOCHALCONE D Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1644932 |
| Name | LICOCHALCONE D |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RETRVWFVEFCGOK-RMKNXTFCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
4.22
ALogP
5
HBA
3
HBD
87.0
PSA (Ų)
0.31
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 5.31 | 5.31 | 4850.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 4850.0 | nM | 5.31 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 24316124 |
| NON-PROTEIN TARGET | IC50 | = | 21000.0 | nM | 4.68 | Antiinflammatory activity in RBL2H3 cells assessed as inhibition of degranulatio... | 24316124 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24316124 | 10.1016/j.bmcl.2013.11.044 | RAW264.7 | 5 |
| 21123068 | 10.1016/j.bmcl.2010.11.016 | Neuraminidase | 3 |
| 28835349 | 10.1016/j.bmc.2017.08.018 | Nuclear factor erythroid 2-related factor 2 | 2 |
| 21123068 | 10.1016/j.bmcl.2010.11.016 | Sialidase | 1 |
| 24316124 | 10.1016/j.bmcl.2013.11.044 | NON-PROTEIN TARGET | 1 |
| 28835349 | 10.1016/j.bmc.2017.08.018 | HepG2 | 1 |
| 37659218 | 10.1016/j.bmc.2023.117454 | Staphylococcus aureus | 1 |
| 37659218 | 10.1016/j.bmc.2023.117454 | Bacillus subtilis | 1 |
| 37659218 | 10.1016/j.bmc.2023.117454 | Micrococcus luteus | 1 |
Data from ChEMBL 36 via Core Engine